Parametric shift from rational to irrational decisions in mice

Rational and Irrational Bubbles

The rational approach to the irrational.

American AssociaUon for the Advancemnt of Science Science serves its readers as a forum for the presentation and discussion of important issues related to the advancement of science, including the presentation of minority or conflicting points of view, rather than by publishing only material on which a consensus has been reached. Accordingly, all articles published in Science-including editoria...

Persistence motives in irrational decisions to complete a boring task.

We explored a novel task paradigm where participants from the online work marketplace Amazon Mechanical Turk were given the choice to quit or continue an unfinished boring task for identical economic rewards. In Studies 1a and 1b, about half the participants chose to continue (corresponding to an average of 55 and 35 cents in foregone earnings). Participants' self-reported reasons for continuin...

Rational Capital Budgeting in an Irrational World

Rational and Irrational Approaches to Convince a Protein to Crystallize

The importance of structural biology has been highlighted in the past few years not only as part of drug discovery programs in the pharmaceutical industry but also by structural genomics programs. Mutations of human proteins have been long recognized as the source of severe diseases and a structural knowledge of the consequences of a mutation might open up new approaches of drugs and cure. Alth...